Brain Stimulation: Chapter 16. Deep brain stimulation for other tremors, myoclonus, and chorea

Deep brain stimulation (DBS) is a well established treatment for essential tremor and for the tremor associated with Parkinson’s disease. The efficacy of DBS in these common tremors has led some investigators to apply the technique to rarer tremors such as such as Holmes’ tremor, posttraumatic tremor, orthostatic tremor, and the tremor associated with multiple sclerosis. Likewise, DBS of the thalamus and globus pallidus directly suppresses levodopa-induced dyskinesias in Parkinson’s disease, suggesting the application of DBS to other hyperkinetic states such as Huntington’s disease, tardive dyskinesia, and hemiballism. Myoclonus has also been treated with DBS, especially in cases where it is associated with dystonia. This chapter reviews the reported results of DBS for these conditions. Due to the rarity of these indications, most of the literature reviewed takes the form of case reports or small single-center case series.