Deadpool (2012) #45

Final issue! That's right, if you add together all the Deadpool series (creatively) issue 45 is the big 250th issue of Deadpool! What better way to celebrate than to end the series? In our over-sized main story, Ultimatum comes at Deadpool for revenge, so he has no choice but to take them on--all of them. Then, in an Infinity Gauntlet crossover, what would Deadpool do if he got the six gems from Thanos? Plus, a slew of stories showcasing Deadpool's closest friends and allies by special guest writers! Also, a spoiler: Deadpool dies at the end of the issue.